Gerard Karsenty, MD, PhD

Portrait of Dr. Gerard Karsenty

Overview

Academic Appointments

  • Paul A. Marks Professor of Genetics and Development
  • Professor of Medicine

Administrative Titles

  • Chair, Genetics and Development Department

Gerard Karsenty M.D., Ph.D., is the Paul A. Marks M.D., Professor and Chair of the Department of Genetics and Development at Columbia University Medical center, New York City. In the last 20 years, his laboratory has studied every aspect of skeletal biology ranging from development to physiology. His laboratory deciphered the molecular bases of osteoblast-specific gene expression, a work that culminated in his identification of Runx2 as the master gene of osteoblast differentiation. This was followed by the identification of an entire cascade of transcription factors regulating osteoblast differentiation and of Gm2 as the master gene of parathyroid gland development. In approaching bone physiology Karsenty proposed that there is a coordinated control endocrine in nature, of bone mass, energy metabolism and fertility. The Karsenty lab has verified in the mouse and whenever possible in humans all tenets of this hypothesis. One of them is that bone should be an endocrine organ regulating energy metabolism and reproduction. This led to the identification of osteocalcin as a bone-derived hormone needed for insulin secretion, glucose homeostasis, testosterone secretion by Leydig cells of the testes and male fertility, brain development cognition and adaptation to exercise. Currently his work focuses through the definition of all functions of osteocalcin in understanding why would bone be an endocrine organ.

Languages

  • French

Credentials & Experience

Education & Training

  • MD, PhD, Physiology, Paris Medical School, France
  • Fellowship: National Institute of Health
  • Fellowship: MD Anderson Cancer Center

Honors & Awards

2017:  Elected Associate Member of EMBO

2017: The AACE Frontiers in Science Award

2016: Steven's Triennial Prize for Excellence in Original Medical Research

2016: Roy E. Greep Award for Excellence in Basic Science, the Endocrine Society

2014: Member National Academy of Medicine

2012: Hoffenberg International Medal British Endocrine Society

2011: ASBMR William F. Neuman Award

2011: Herbert Fleisch Achievement Award in Basic Science, IOF

2011: Senior Scholar in Aging Ellison Foundation

2010: Jacobaeus Prize NovoNordisk Foundation, Denmark

2010: Member, College of CSR Reviewers, NIH

2010: Richard Lounsbery Award, National Academy of Science (USA), Academie des Sciences (France)

2008: Lee C. Howley Prize for Arthritis Research, Arthritis Foundation

2007: Schaefer Award, Columbia University Medical Center

2007: Drieu-Cholet Award, The French National Academy of    Medicine

2006: Edith and Peter O’Donnell Award, The Academy of Medicine, Engineering and Science of Texas

2002: Member of The Association of American Physicians

2001: Louis V. Avioli Founders Award of the ASBMR

2001: D. Harold Copp Award of the IBMS

2000: Michael E. De Bakey Excellence in Science Award

1997: Research Award of the Austrian Bone and Mineral Research Society

1996: International Bone and Calcium Institute Young Scientist Award

1985: French Endocrine Society Award for Young Scientists

Research

Genetics to understand Development, Physiology and Pathogenesis of all diseases

Grants

REGULATION OF ADRENAL STEROIDOGENESIS BY THE SKELETON (Private)

Jun 1 2018 - May 31 2021

KEREN THERAPEUTICS, INC. (Private)

Feb 6 2018 - Feb 5 2019

Selected Publications

1: Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007 Aug 10;130(3):456-69. 

2: Ferron M, Wei J, Yoshizawa T, Del Fattore A, DePinho RA, Teti A, Ducy P, Karsenty G. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell. 2010 Jul 23;142(2):296-308. doi:10.1016/j.cell.2010.06.003. 

3: Oury F, Sumara G, Sumara O, Ferron M, Chang H, Smith CE, Hermo L, Suarez S, Roth BL, Ducy P, Karsenty G. Endocrine regulation of male fertility by the skeleton. Cell. 2011 Mar 4;144(5):796-809. doi: 10.1016/j.cell.2011.02.004. Epub 2011 Feb 17.

4: Oury F, Khrimian L, Denny CA, Gardin A, Chamouni A, Goeden N, Huang YY, Lee H, Srinivas P, Gao XB, Suyama S, Langer T, Mann JJ, Horvath TL, Bonnin A, Karsenty, G. Maternal and offspring pools of osteocalcin influence brain development and functions. Cell. 2013 Sep 26;155(1):228-41. doi: 10.1016/j.cell.2013.08.042.

5: Wei J, Shimazu J, Makinistoglu M, Maurizi A, Kajimura D, Zong H, Takarada T, Iezaki T, Pessin JE, Hinoi E, and Karsenty G. Glucose uptake and Runx2 synergize to orchestrate osteoblast differentiation and bone formation. Cell. 2015 161 (7): 1576-91.

6: Mera P, Laue K, Ferron M, Confavreux C, Wei J, Galan-Diez M, Lacampagne A, Mitchell SJ, Mattison JA, Chen Y, Bacchetta J, Szulc P, Kitsis RN, de Cabo R, Friedman RA, Torsitano C, McGraw TE, Puchowicz M, Kurland I and Karsenty G. Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise. Cell Metab. 2016 23 (6):1078-92.