Research Labs

  • The Berchowitz Lab employs genetic, cell biological, and biochemical approaches to understand the pathways and mechanisms underlying formation and clearance of amyloid-like assemblies.

  • Our lab investigates the epigenomics of complex human diseases in a systematic genome-wide fashion.

  • The Cardoso lab focuses on mechanisms that regulate lung progenitor cell fate during lung development and the contribution of developmental mechanisms to disease pathogenesis and regeneration-repair.

  • The Chio Lab aims to test the therapeutic principle that the specific redox dependencies of PDA cells can be exploited to target tumor cells while sparing normal tissues.

  • Our lab studies inherited skin and hair disorders using a classical genetic approach through identification and phenotyping of disease families, genetic linkage, gene discovery and mutation analysis.

  • The Ciccia Lab investigates how genome instability causes cancer and other genetic disorders.

  • The Costantini lab studies the genetic control of epithelial branching morphogenesis during kidney development in the mouse.

  • The general goal of this laboratory is to elucidate the pathogenesis of cancers derived from B lymphocytes, known as B cell lymphomas.

  • The Frankel Lab is devoted to understanding the genetic basis of neurological disorders with an emphasis on epilepsy and closely related synaptic disorders that include seizures.

  • The Gautier Lab uses Xenopus laevis cell-free extracts to study DNA replication and repair.

  • The Gennarino Lab's overarching goal is understanding molecular mechanisms that underlie neurological and neuropsychiatric diseases and symptoms, in the hope of ultimately devising viable therapies.

  • Studying disease causing genes and new treatment options targeted to the underlying causes of disease.

  • The main focus of the Hobert Lab is to understand the gene regulatory control mechanisms that generate the astounding diversity of cell types in the nervous system.

  • Fitness sensing during organ and tissue growth: internal surveillance mechanisms that promote healthy organ development

  • The Karsenty Lab studies all aspects of skeletal biology.

  • The Lu Lab is interested in understanding basic mechanisms governing chromatin organization and access during normal and cancer development.

  • The Mann Lab studies the Hox family of transcription factors and the neural circuitry required for coordinated walking in adult flies.

  • A close-up of urothelial progenitors

    We investigate urothelial progenitors important for formation, homeostasis and regeneration of the urothelium, and identification of urothelial cell types that give rise to bladder cancers.

  • The Ohlstein Lab is investigating the role of stem cells in tissue homeostasis and organogenesis.

  • Our laboratory studies how hematopoietic stem cells (HSC) regulate blood production during the lifetime of an ever-changing organism.

  • By using budding yeast as an experimental organism, the Rothstein Lab studies essential biological processes such as the mechanisms underlying the recognition and repair of DNA damage.

  • Mitochondrial genetics and the molecular basis of human mitochondrial disease.

  • Investigating molecular mechanisms of mammalian development and cancer using in vivo analyses of genetically-engineered mouse models.

  • The Shirasu-Hiza Lab seeks to understand how the circadian clock regulates immune cells using the model organism Drosophila melanogaster.

  • The Struhl Lab studies organ growth, cell patterning, and cell-cell signaling.

  • The Symington lab uses the yeast Saccharomyces cerevisiae as a model eukaryotic genetic system to determine the mechanisms of mitotic/somatic genome stability.

  • Population genetic epidemiology and gene mapping.

  • Cellular interactions in Drosophila development.

  • The Wolgemuth lab focuses on understanding the genetic control of gametogenesis and embryogenesis using mouse models and gene targeting, transgenic, and molecular and cell biological approaches.

  • The Yan laboratory at Columbia focuses on understanding tissue renewal in health and disease using the mammalian intestine as a model system to study adult stem cell biology.

  • The two major research interests of the Zhang Lab are epigenetic inheritance and cancer epigenetics.