Wayne Frankel, PhD

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Overview

Academic Appointments

  • Professor of Genetics and Development (in the Institute for Genomic Medicine) at CUMC

Gender

  • Male

Research

My research is devoted to understanding the genetic basis of neurological disorders with an emphasis on epilepsy and a growing interest in closely related synaptic disorders that include seizures, such as autism and intellectual disability.

My focus is on better modeling epilepsy at the physiological and molecular level using a multidisciplinary approach - genetics, genomics, cell biology and biochemistry - in genes encoding ion channels, synaptic molecules, RNA binding proteins and others. We are currently modeling severe pediatric epileptic encephalopathies in laboratory mice. Much of our research is part of a multi-platform close collaboration with other members of the Institute for Genomic Medicine (IGM), towards development of precision medicine-based novel therapies.  I also provide oversight in mouse genetics, genomics and biology for the IGM as its director of preclinical models, and am the program director of the Mouse Neurobehavioral Core (MNBC), to open in 2017

Grants

THE JACKSON LABORATORY CENTER FOR PRECISION GENETICS: FROM NEW MODELS TO NOVEL THERAPEUTICS (Federal Gov)

Aug 15 2015 - Jun 30 2020

RNA BINDING PROTEINS IN COMPLEX NEUROLOGICAL DISEASE (Federal Gov)

Feb 1 2015 - Jan 31 2020

GENETIC DETERMINANTS OF EPILEPSY IN MURINE SYSTEMS (Federal Gov)

Jan 1 2016 - Dec 31 2018

Selected Publications

1. Asinof S, Mahaffey C, Beyer B, Frankel WN, Boumil R. : (2016) Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy..  Neurobiology of Disease  95: 1-11 

2. Asinof SK, Sukoff Rizzo SJ, Buckley AR, Beyer BJ, Letts VA, Frankel WN, Boumil RM.: (2015) Independent Neuronal Origin of Seizures and Behavioral Comorbidities in an
Animal Model of a Severe Childhood Genetic Epileptic Encephalopathy.  PLOS Genetics  11: e1005347 

3. Wagnon JL, Briese M, Sun W, Mahaffey CL, Curk T, Rot G, Ule J, Frankel WN.: (2012) CELF4 regulates translation and local abundance of a vast set of mRNAs, including
genes associated with regulation of synaptic function.  PLOS Genetics  8: e1003067 

4. Sun W, Wagnon JL, Mahaffey CL, Briese M, Ule J, Frankel WN: (2013) Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice.  Journal of Physiology  591: 241-255 

5. Wagnon JL, Mahaffey CL, Sun W, Yang Y, Chao HT, Frankel WN: (2011) Etiology of a genetically complex seizure disorder in Celf4 mutant mice.  Genes, Brain and Behavior  10: 765-777 

6. Boumil RM, Letts VA, Roberts MC, Lenz C, Mahaffey CL, Zhang ZW, Moser T, Frankel WN.: (2010) A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice.  PLOS Genetics  6: e1001046