Yousin Suh, PhD

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Overview

Yousin Suh is the Charles and Marie Robertson professor of reproductive sciences in obstetrics and gynecology, professor of genetics and development, and director of reproductive aging at Columbia University. She investigates the (epi)genetic component that underlies the interface of intrinsic aging and disease. Her approach is based on the identification of (epi)genome sequence variants associated with age-related disease risk or its opposite, that is, an unusual resistance to such disease.

Her target populations are either cohorts of middle-aged individuals followed longitudinally for signs of all major age-related diseases or cohorts of extremely long-lived individuals who managed to ward off such diseases. To tackle the key problem of identifying the functional impact of any observed association, she applies specific functional tests, including in silico modeling, cell culture assays and mouse models. Her discoveries so far include novel, rare alleles associated with extreme longevity, sirtuin variants that confer risk of heart disease, functional noncoding variants in the gene desert chromosome 9p21 locus underlying multiple age-related diseases, longevity-associated microRNAs, and epigenetic signatures of cellular senescence.

Her contributions have been recognized with the Glenn Award for Research in Biological Mechanisms of Aging. She has organized numerous international symposiums on the functional genomics of aging, sits on the editorial boards of numerous journals including PLoS Genetics and Aging Cell as an associate editor, and is a member of advisory committees for several research institutions and companies.

Academic Appointments

  • Professor of Reproductive Sciences (in Obstetrics and Gynecology)
  • Professor of Genetics & Development

Gender

  • Female

Research

Grants

GENETIC CORRELATION AND CAUSAL RELATIONSHIP AMONG ALZHEIMER S DISEASE AND OTHER AGE-RELATED DISEASES AND TRAITS (Federal Gov)

Oct 1 2019 - Apr 30 2022

HUMAN TISSUE SPECIFIC AGE-RELATED GENE EXPRESSION CHANGES, THEIR GENETIC REGULATIONS AND THE LINK TO HUMAN DISEASES (Federal Gov)

Oct 1 2019 - Nov 30 2020

COMBINATORIAL ACTIONS OF GENETIC VARIANTS AND GENDER BIAS OF ALZHEIMER S DISEASE (Federal Gov)

Oct 1 2019 - May 31 2020

COMBINATORIAL ACTIONS OF GENETIC VARIANTS AND GENDER BIAS OF ALZHEIMER S DISEASE (Federal Gov)

Oct 1 2019 - May 31 2020

FROM IN VIVO TO IN VITRO HETEROCHRONIC PARABIOSIS TO IDENTIFY GERONIC FACTORS (Federal Gov)

Jan 1 2020 - Mar 31 2020

SYSTEMS MODELING OF ALZHEIMERS DISEASE IN C. ELEGANS (Federal Gov)

Jan 1 2020 - Mar 31 2020